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What
you have here is the result of thousands of hours of work compiling
from peer-reviewed sources a vast collection of data related to
Parkinson's Disease. Once compiled, the data was sorted into a logical
framework and placed here for your own evaluation and comment. It is
hoped that this will serve as a "seed" as well as an educational tool
and that others, both professional and patient alike, will add their
own input by way of the forums. As errors are corrected and consensus
reached this will be altered and grow.
(Note: Links to each module are being actively developed and added several times per week. Check back often.)
PD Outline Index
- ~ 0 – Introduction and General Factors
- ~ 1 - The Subjective Nature of Parkinson’s Disease
- ~ 1.01 - Fragility
- ~ 1.02 - Multitasking
- ~ 1.03 - Freezing
- ~ 1.04 - Common Elements of Personal Histories
- ~ 2 - The Objective Nature of Parkinson’s Disease
- ~ 2.01 - Tremor
- ~ 2.02 - Movement
- ~ 2.03 - Substantia Nigral Cell Loss
- ~ 2.04 - Lewy Bodies
- ~ 2.05 - Alpha Synuclein
- ~ 2.06 - Neuropathy
- ~ 2.07 - Symptoms and Their Control
- ~ 2.08 - Olfactory Bulb
- ~ 3 - Degenerative Processes in PD
- ~ 3.01 - Inflammation
- ~ 3.02 - Oxidation
- ~ 3.03 - Autoimmune Response
- ~ 3.04 - Mitochondrial Dysfunction
- ~ 3.05 - Misfolded Proteins
- ~ 3.06 - Chronic Stress
- ~ 3.07 - Glutamate and Excitotoxicity
- ~ 4 - Primary Causal Factors
- ~ 4.01 - Prenatal Environment
- ~ 4.02 - Chronic Bacterial Endotoxin Exposure and PD
- ~ 4.03 – Endocrine System. HPAA, and Stress Response
- ~ 4.04 - Chronic Neuroinflammation
- ~ 4.04.01 - Mitochondrial Impairment
- ~ 4.04.02 - Systemic Effects
- ~ 4.05 - Inflammation and Endothelial Failure
- ~ 4.05.01 - Endothelial Failure and “Leaky Gut”
- ~ 4.05.02 - Endothelial Failure and the Blood Brain Barrier
- ~ 4.06 - Rhythm Disruption and Sleep
- ~ 4.06.01 – Circadian
- ~ 4.06.02 – Neural
- ~ 4.06.03 - Sleep Disruption
- ~ 4.06.04 - Olfactory Bulb
- ~ 4.06.05 - VIP and Rhythm
- ~ 4.06.06 - Electrolytes and Rhythm
- ~ 4.07 - Cytokines, Hormones, and Disruption of Neurofunction
- ~ 4.07.01 – Neuroactive Cytokines
- ~ 4.07.02 - Neuroactive Hormones
- ~ 4.08 - Metabolic and Nutritional Factors
- ~ 4.08.01 - Malabsorption
- ~ 4.08.02 - Hyper and Hypoglycemia
- ~ 4.08.03 - Food Intolerence
- 4.08.04 - Lectins and Cross-Reactivity
- ~ 4.09 - Neuropeptide Dysfunction
- ~ 4.09.01 - VIP and Substance P
- ~ 4.10 – Acquired Traits and Genetics
- ~ 4.11 - Hypoxia
- ~ 4.12 - Cellular Disorders
- ~ 4.12.01 - Ion Channel Disorders
- ~ 4.12.02 - Proteasomes
- ~ 4.13 - Pathogens
- ~ 4.14 - Related Disorders
- ~ 4.14.01 - PTSD
- ~ 4.14.02 - schizophrenia
- ~ 4.14.03 - Autism
- ~ 4.14.04 - Diabetes
- ~ 4.14.05 - Depression
- ~ 4.14.06 - Metabolic Syndrome
- ~ 4.15 - Gastrointestinal Factors
- ~ 4.16 - Electrolytes
- ~ 4.17 - Vagal Nerve
- ~ 5 - Failings of the Current Hypothesis
- ~ 6 - Towards a New Hypothesis
- ~ 6.01 - Interacting Systems
- ~ 7 - Therapeutic Possibilities
- ~ 7.01 - antidepressants
- ~ 7.02 - blue light
- ~ 7.03 - brainwave entrainment
- ~ 7.04 - dextromethorphan
- ~ 7.05 - dietary
- ~ 7.06 - gingko
- ~ 7.07 - ginseng
- ~ 7.08 - inflammation
- ~ 7.09 - light therapy
- ~ 7.10 - LPS protection
- ~ 7.11 - melatonin
- ~ 7.12 - mitochondria
- ~ 7.13 - music therapy
- ~ 7.14 - NMDA receptors
- ~ 7.15 - omega 3s
- ~ 7.16 - polymyxin b
- ~ 7.17 - royal jelly
- ~ 7.18 - silymarin
- ~ 7.19 - stress diet
- ~ 7.20 - triptolide
- ~ 7.21 - turmeric curcumin
- 7.27 - mucuna pruriens