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An Online Think Tank About Parkinson's Disease
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About New Member Registration
A Matter of Balance - A Blog
Caduceus - Part Pub, Part Cafe - A place to talk.
The Parkinson's - Stress Project
-----The Results of a Survey of PWP---------------------------------------------
-----Stress, PD, and the Endocrine System--------------------------------------
A Summation
A New Look at Parkinson's
1.00 The Problem With Parkinson's Disease -----------------------------------------------
---------1.0 Discussion---------------
2.00 The Reality of Parkinson's Disease---------------------------------------
-----2.01 Symptoms--------------------------------------
----------2.01.01 Blood Pressure --------------------------
-----2.02 Side Effects of Medications-----------------------------------------
----------2.02.01 Dyskinesias------------------------------
----------2.02.02 Mitochondrial Inhibition---------------------------
-----2.03 PD Through History----------------------------------------
-----2.04 Newly Diagnosed?--------------------------------------------
----------2.0 Discussion------------
3.00 So, What is PD? The Chinese Restaurant Model------------------------
-----3.01 Multiple factors from the Beginning-----------------------------
-----3.02 Ongoing Processes Throughout Life-------------------------------
----------3.02.01 Inflammation and LPS---------------------------
----------3.02.02 Oxidation--------------------------------
----------3.02.03 Mitochondrial failure-----------------------------
----------3.02.04 Chronic Stress Response---------------------------
----------3.02.05 Autoimmunity----------------------------
----------3.02.06 Misfolded Proteins-----------------------------
----------3.02.07 Excitotoxicity------------------------------
----------3.02.08 Microglial Activation-------------------------------
----------3.02.09 Endothelial Failure--------------------------------
-----3.03 System Collapse at the End------------------------------
----------3.03.01 Autonomic Failure----------------------------
----------3.03.02 Adrenal Collapse------------------------------
----------3.0 Discussion----------
A Cascade of Causes and Contributions
4.01 Prenatal Environment and Parkinson's Disease-------------------------------
-----4.01.01 Prenatal LPS--------------------------------------
-----4.01.02 Prenatal Stress--------------------------------------
-----4.01.03 Prenatal Programming and the Adult--------------------------------------
----------4.01 Discussion---------------------
4.02 Chronic Exposure to Bacterial Endotoxin LPS and Parkinson's Disease---------
-----4.02.01 Individual Sensitivity-----------------------------------------
-----4.02.02 LPS and the CNS-------------------------------------
-----4.02.03 LPS and the Immune System-------------------------------------------
4.02.03.01 Inflammation
4.02.03.02 Neuroinflammation
4.02.03.03 Microglial Activation
4.02.03.04 Autoimmune / Autotoxic Response
-----4.02.04 LPS and the Endocrine System--------------------------------------
-----4.02.05 LPS and the GI System----------------------------------------
-----4.02.06 LPS and PD Linkages---------------------------------------
-----4.02.07 LPS Sources--------------------------------------
-----4.02.08 LPS Detoxification----------------------------------------
----------4.02 Discussion----------
4.03 Endocrine System, Stress, and Parkinson's Disease---------
-----4.03.01 The Endocrine System and the HPAA--------
-----4.03.02 The HPAA and Parkinson's Disease
-----4.03.03 Stress and Parkinson's Disease
-----4.03.04 Stress and the Nervous System
-----4.03.05 Stress and the Immune System
-----4.03.06 Stress and the GI system
-----4.03.07 Variations in stress sensitivity
----------4.03 Discussion----------------
4.04 Chronic Neuroinflammation and Parkinson's Disease-----------------------------
----------4.04 Discussion--------------------------------
4.05 Inflammation, Endothelial Failure, and Parkinson's Disease---------------------
-----4.05.01 Inflammation---------------------------------
-----4.05.02 Endothelial Failure and Leaky Gut-----------------------------
-----4.05.03 Endothelial Failure and the Blood Brain Barrier-----------------------------
----------4.05 Discussion-----------------------------
4.06 Disruption of Rhythm and Sleep in Parkinson's Disease------------------
-----4.06.01 Time keeping rhythms and PD-------------------------------------
-----4.06.02 Circadian Rhythms and PD--------------------------
-----4.06.03 Sleep and PD-----------------------------
4.07 Cytokines, Hormones, Neurotransmitters, and Disruption of Neurofunction-----
-----4.07.01 Neuroactive Chemistry and Parkinson's Disease----------------
-----4.07.02 Cytokines-------------------------
-----4.07.03 Hormones---------------------------
----------4.07.03.01 Cortisol and CRH--------------------------------------
4.07.03.02 Insulin and glucose--------------------
4.07.03.03 Testosterone------------------------
4.07.03.04 Estrogen-----------------
4.07.03.05 Corticotropin-releasing hormone-----------
4.07.03.06 Melatonin------------------
-----4.07.04 Neurotransmitters------------------------
----------4.07.04.01 Dopamine Synthesis Problems--------------------
----------4.07.04.02 Dopamine Destruction---------------------------
----------4.07.04.05 Noradrenaline--------------------------
----------4.07.04.10 Serotonin------------------------------
----------4.07 Discussion-----------------------------
4.08 Metabolic and Nutritional Factors in Parkinson's Disease-------------------------
-----4.08.01 Diabetes, Glycemia, and Parkinson's Disease-------------------------------
-----4.08.02 Metabolic Syndromes and Parkinson's Disease
-----4.08.03 Nutrient Malabsoption, Transport, Enzymes, Co-factors
-----4.08.04 Food Intolerance, Lectins, and Cross Reactivity
-----4.08.05 Vitamin D3 -----------------------------
-------------------------4.08 Discussion-------------------------
4.09 Neuropeptide Dysfunction------------------------------
4.10 Genetics and Epigenetics---------------------------------
4.11 Hypoxia------------------------------------------------------------
4.12 Cellular Disorders--------------------------------------------------------------------------
-----4.12.01 Mitochondrial Dysfunction-----------------------------
4.13 Pathogens---------------------------------------------------
4.14 Related Disorders---------------------------------------------------------------
-----4.14.10 Normal Pressure Hydrocephalus---------------------------------------
-----4.14.11 Post Traumatic Stress Disorder---------------------------
4.15 Gastrointestinal Factors-----------------------------------------------------
---------------4.15 Discussion-----------------
4.16 Electrolytes and PD---------------------------------------------------
4.17 Vagus Nerve----------------------------------------------------
4.18 Neuromelanin, Alpha Synuclein, Misfolded Proteins, and Lewy Bodies----
4.18.01 Neuromelanin----------------------------
4.18.02 Alpha Synuclein-------------------------
4.18.03 Misfolded Proteins-------------------------
4.18.04 Lewy Bodies-----------------------
4.19 Pollutants and Environmental Toxins----------------------------
4.19.01 Ultra Fine Particulates and Braak Staging
4.19.01.01 Ultra Fine Particulates
4.19.01.02 Braak Staging
4.19.01.03 Points of Entry - Olfactory Bulb and Gastric Wall
4.19.01.04 UFP, LPS, and Neuronal Transport
4.19.02 Pesticides, Herbicides, and PD
4.20 Vaccines, Dental Amalgams, and Other Controversies---------------
Systems and Synergy
10.01 Synergy and Amplification of Effect-------------------
10.02 Immune System and PD--------------------------
-----10.021 PD, Lipopolysaccharide (LPS), and Microglia in the SN--------------------------
----------10.02 Discussion--------------------------------
-----10.020 Overview Immune PD Interacton-----------------
10.03 Endocrine System and PD-------------------
-----10.030 Endocrine - PD Overview--------------------------------
-----10.031 PD, Cushing's Syndrome, and System Collapse----------------------------
-----10.032 PD, Glycemic Control, and Hyperglycemia------------------------------
----------10.03 Discussion----------------------------
10.04 GI System and PD--------------------
-----10.041 PD, Constipation, and Leaky Gut----------------------------
----------10.04 Discussion---------------------------
10.05 Nervous System and PD-----------------
-----10.051 PD and Neuroactive Chemistry---------------------------
----------10.05 Discussion-----------------------------
10.06 System Interactions - PD as a Whole
-----10.06.01 Immune and CNS interactions------------------------------
-----10.06.02 Immune (LPS) and Endocrine (HPA)----------------------
----------Discussion---------
Therapeutic Possibilities
About this section - must read!---------------------------------------
20.1 Botanical Therapies------------------------------
-----20.11 Turmeric / Curcumin-(Protective, Adaptogen)--------------------------------
-----20.12 Ginkgo biloba--(Protective, adaptogen, mitochondria)----------------------------
-----20.13 Ashwagandha--(Restorative, functional)---------------------------
-----20.14 Astragalus--(Restorative)-------------------------------
-----20.15 Ginseng---(Restorative, protective, adaptogen)-------------------------
-----20.16 Royal jelly--(Restorative, protective)-----------------------------
-----20.17 Green tea / Theanine-------------------------
-----20.18 Silymarin---(Protective) -------------------------
-----20.19 Triptolide (Protective)---------------------------
-----20.20 Baicalein--(Restorative, Protective)----------------------------
-----20.21 Mucuna pruriens------------------------------
-----20.22 Spikenard--(Restorative)----------------------------
-----20.23 Rhodiola--------------------------------
-----20.24 Bilberry--(Protective, mitochondria)----------------------------
-----20.25 Resveratrol------------------------------
-----20.26 Boswellia-----------------------------
-----20.27 St. John's Wort------------------------------
-----20.28 Kava kava-----------------------------
-----20.29 Valerian--------------------------------
-----20.30 Bacopa monniera----------------------------
-----20.31 Convolvulus pluricaulis---------------------------
-----20.32 Ginger----------------------------------
------20.33 General Polyphenols------------------------------
----------20.1 Discussion-------------------------
22.1 Dietary supplements--------------------------------
-----22.11 L-Arginine-----------------------------------------------------------
-----22.12 Methionine-------------------------------
-----22.13 Vitamin D3-----------------------------
-----22.14 Folic Acid---------------------------------
-----22.15 Creatine-----------------------------
-----22.16 Acetyl-L-Carnitine/Alpha-Lipoic-Acid-------------------------
-----22.17 CDP-Choline------------------------------
25.1 Mitigation Therapies----------------------------
-----25.11 Antioxidants---------------------------------
-----25.21 Anti-inflammatories--------------------------------
-----25.31 Anti-stress-------------------------------
30.1 Metabolic Therapies and Parkinson's------------------------------
----------30.1 Discussion------------------------------
40.1 Orphanned Therapies-------------------
------40.11 Vibrational therapy-----------------------------
-----40.12 Light Therapy--------------------------------
-----40.13 Methylene Blue---------------------------
----------40.1 Discussion-------------------------
50.1 Hormonal Therapies-------------------------
----------50.1 Discussion----------------------
60.1 Peptide Therapies-----------------------------
-----60.11 GLP-1, CRF-1, Ex-4-----------------------------
-----60.12 GLP-1 Therapy---------------------------
-----60.13 CRF-1 Therapy---------------------------
-----60.14 Nerve Growth Factors Therapy----------------------------
----------60.1 Discussion---------------------------
70.1 Dietary Therapies-----------------------------
-----70.11 Fats and fatty acids--------------------------------------------
-----70.12 Dopamine Precursors----------------------------------------
-----70.13 Caloric Restriction----------------------------------
-----70.14 Micronutrients---------------------------------
----------70.1 Discussion------------------------------
80.1 Electrical stimulation-----------------------------
----------80.1 Discussion------------------------------
90.1 Ayurveda and TCM------------------------------
----------90.1 Discussion--------------------------------
Administration
FAQs
-----------Discussion-----------
Patient's Voices
To Doctors-----------------------------------------------
To Researchers--------------------------------------
-----------Discussion----------
The White Rats-----------------------------
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