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Hypotheses


About this Work

The HypothesesPreliminary ConclusionsDiscussion
What's New:  Damn near everything.

"The advantages which have been derived from the caution with which hypothetical statements are admitted, are in no instance more obvious than in those sciences which more particularly belong to the healing art. It therefore is necessary, that some conciliatory explanation should be offered for the present publication: in which, it is acknowledged, that mere conjecture takes the place of experiment; and, that analogy is the substitute for anatomical examination, the only sure foundation for pathological knowledge." 

"When, however, the nature of the subject,and the circumstances under which it has been here taken up, are considered, it is hoped that the offering of the following pages to the attention of the medical public, will not be severely censured. "      James Parkinson, London, 1817



All knowledge is an expanding phenomenon and this is no exception.  Nothing is set in stone.



The Reality Which Must Be Accounted For

While it is common to think of problems with movement when one thinks of PD symptoms, there is much more. So much more, in fact, that the term "movement disorder" quickly comes into question.


From http://www.pdindex.org/, for example, there is:


Primary symptoms of PD

1. Tremor
2. Muscular stiffness and rigidity
3. Bradykinesia (slow movement), akinesia (poverty of movement)
4. Impaired balance (postural instability)

It is somewhat misleading to label these as the "primary" symptoms as though they were most important. It is often the "secondary" symptoms that most impact the patient. Depression, for example, can be far more devastating than, say, tremor. In addition, the categorization of relative status of symptoms would vary were age and gender factored in.

I understand that there is a certain amount of semantics involved here, but that is one of the problems. Define PD by the traditional symptoms above, add in the importance of l-dopa, and suddenly you have a "movement disorder" by definition - but not by observation! And it does little to justify this semantic "tidying up" to claim that those four are universal while others are not. That is not true, for one thing, and, even if it were, the label would still be misleading.

I don't intend to belabor the point. But the fact is that much emphasis has been placed upon those "primary" factors as a matter of convenience (after all, they are certainly not subtle) and has led to the "secondary" status of some very important clues:


OTHER SIGNS & SYMPTOMS

All these (and more) are part of Parkinson's Disease and must therefore must be accounted for by any complete theory. We do not hope to reach that level here. But the closer we come the better our work.


One final point - the complex symptomology noted above illustrates the individual nature of this disorder. And the term "disease" may itself be misleading.


A Basic Requirement

Hypotheses lead to theories and theories must meet a basic requirement and must meet it completely - they must reflect reality.

A theory which fails to do so is incomplete and one which runs counter to reality is wrong.

With these simple facts in mind, it is appropriate to list the symptoms and other matters related to Parkinson's Disease that must be accounted for if a theory is to be thought of as a valid reflection of reality, for this IS the reality of PD.